Article

Loss of lysyl hydroxylase 2 activates CRP-mediated cancer invasion through MEK/ERK/MMP9 signaling in the bone-microenvironment

2026-01-12

Abstract excerpt

<title>Abstract</title> <p> Lysyl hydroxylase 2 (LH2), encoded by <italic>procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2</italic> ( <italic>Plod2</italic> ) gene, plays critical roles in collagen cross-linking and bone matrix organization. Recent studies have also shown that aberrant LH2 expression is promotes tumor progression, but its specific role in modulating cancer behavior within the bone-microenv...

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Literature Corpus work: f5be0a84-d7d5-5989-91be-0c3354339013
DOI: 10.21203/rs.3.rs-7989174/v1

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