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Article

Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration.

Biochemical and biophysical research communications - 8 Jan 2022

Nozaki Ryunosuke, Kasamatsu Atsushi, Moss Joel, Uzawa Katsuhiro

Abstract excerpt

Lysyl hydroxylase 2 (LH2) regulates intermolecular cross-linking of collagen molecules. Accumulation of LH2-modified collagen, which is highly stable and resistant to collagenase cleavage, is one cause of fibrosis. We previously demonstrated that conventional LH2 knockout mice showed embryonic lethality. Here we established LH2 conditional knockout mice using a tamoxifen-inducible Cre system. Morphological...

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Identifiers

PMID: 34875533
DOI: 10.1016/j.bbrc.2021.11.100
PMCID: PMC10020999

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