Article

Structural insights into a conserved mechanism of choline translocation through CHT

2025-10-01

Abstract excerpt

<h4>Summary</h4> The essential nutrient choline is critical for cellular homeostasis across all domains of life. In humans, choline uptake in cholinergic neurons for its recycling into acetylcholine is mediated by the high-affinity Na⁺-dependent transporter SLC5A7 (also known as CHT1). Prokaryotes also depend on choline as an osmo-protectant and as metabolite, raising the possibility that bacteria also possess ch...

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Literature Corpus work: f57c10c0-f823-5956-878b-83246a31f73f
DOI: 10.1101/2025.09.30.678764

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