Article

Effects of long-term fasting: longitudinal epigenetic responses in humans

2026-06-17

Abstract excerpt

Prolonged fasting induces marked metabolic adaptations, but whether such time-limited yet intensive interventions engage molecular processes related to biological aging in humans remains unclear. To address this, we investigated physiological and epigenetic responses to a 12-day medically supervised fasting intervention with longitudinal follow-up in 32 participants. Fasting elicited coordinated systemic physiolog...

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Literature Corpus work: f5331c4c-8d08-5568-ba8d-ec6990872246
DOI: 10.64898/2026.06.12.731903

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