Article

Reference genome and transcriptome informed by the sex chromosome complement of the sample increases ability to detect sex differences in gene expression from RNA-Seq data

2019-06-12

Abstract excerpt

<h4>Background</h4> Human X and Y chromosomes share an evolutionary origin and, as a consequence, sequence similarity. We investigated whether sequence homology between the X and Y chromosomes affects alignment of RNA-Seq reads and estimates of differential expression. We tested the effects of using reference genomes and reference transcriptomes informed by the sex chromosome complement of the sample’s genome on...

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Literature Corpus work: f5212d00-bdd9-53a5-ac8b-c02c744d603b
DOI: 10.1101/668376

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