Article

Reduction of human Alzheimer’s disease risk and reversal of mouse model cognitive deficit with nucleoside analog use

2023-03-21

Abstract excerpt

Innate immune signaling through the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer’s disease (AD), the most prevalent form of dementia. We previously demonstrated that nucleoside reverse transcriptase inhibitors (NRTIs), drugs approved to treat HIV and hepatitis B infections, also inhibit inflammasome activation. Here we report that in humans, NRTI exposure was associated with a significan...

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Identifiers and source

Literature Corpus work: f4f35cac-fb24-5555-af40-9dc729eee0ae
DOI: 10.1101/2023.03.17.23287375

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