Article

miR-34a-5p targets Foxp1 to promote osteoclast differentiation and accelerate fracture healing

2025-07-22

Abstract excerpt

<title>Abstract</title> <p>Fracture healing is an intricate biological process that is dependent on osteoblast differentiation. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally, and these molecules participate in osteoblast regulation in bone-related diseases; however, the role of miR-34a-5p in osteoblast differentiation during fracture healing remains unclear. In this study, miR-34a-5p expressi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3ee12b9-bfed-5e96-8c38-9747517b1037
DOI: 10.21203/rs.3.rs-7121624/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

miR-34a-5p targets Foxp1 to promote osteoclast differentiation and accelerate fracture healingDOI 10.21203/rs.3.rs-7121624/v1Read

MicroRNA-497-5p stimulates osteoblast differentiation through HMGA2-mediated JNK signaling pathwaySemantic proximity Read

Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathwaySemantic proximity Read

The lncRNA Rhno1/miR-6979-5p/BMP2 Axis Modulates Osteoblast DifferentiationSemantic proximity Read

LINC00899 promotes osteogenic differentiation and alleviates osteoporosis via targeting miR-374a to regulate RUNX2Semantic proximity Read

ZFP36, an RNA-binding protein promotes hBMSCs osteogenic differentiation via binding with JUNSemantic proximity Read

Diagnostic value and fracture healing-preventing effect of upregulated microRNA-4534 in patients with osteoporotic fracturesSemantic proximity Read

Long non‑coding RNA RP11‑84C13.1 promotes osteogenic differentiation of bone mesenchymal stem cells and alleviates osteoporosis progression via the miR‑23b‑3p/RUNX2 axisSemantic proximity Read

Circ_0027885 sponges miR‐203‐3p to regulate RUNX2 expression and alleviates osteoporosis progressionSemantic proximity Read

Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblastsSemantic proximity Read

The regulatory effect of miR-181c-5p on the differentiation function of bone marrow mesenchymal stem cells in postmenopausal osteoporotic miceSemantic proximity Read

LncRNA ENST00000563492 promoting the osteogenesis–angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by functions as a ceRNA for miR-205-5pSemantic proximity Read

MiR-486-3p promotes osteogenic differentiation of BMSCs by targeting CTNNBIP1 and activating Wnt/β-catenin pathwaySemantic proximity Read