Article

MicroRNA-497-5p stimulates osteoblast differentiation through HMGA2-mediated JNK signaling pathway

2020-07-14

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Osteoporosis (OP) has the characteristics of the decline in bone mineral density and worsening of bone quality, contributing to higher risk of fractures. Some microRNAs (miRNAs) have been validated as possible mediators of osteoblast differentiation. We herein aimed to clarify whether miR-497-5p regulates differentiation of osteoblasts in MC3T3-E1 cells.<bold>Me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c86f856a-9f70-5c51-b262-89c0b5400160
DOI: 10.21203/rs.3.rs-41299/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-497-5p stimulates osteoblast differentiation through HMGA2-mediated JNK signaling pathwayDOI 10.21203/rs.3.rs-41299/v1Read

LINC00899 promotes osteogenic differentiation and alleviates osteoporosis via targeting miR-374a to regulate RUNX2Semantic proximity Read

Circ_0027885 sponges miR‐203‐3p to regulate RUNX2 expression and alleviates osteoporosis progressionSemantic proximity Read

The lncRNA Rhno1/miR-6979-5p/BMP2 Axis Modulates Osteoblast DifferentiationSemantic proximity Read

MiR-545-3p Upregulated in Osteoporosis and Regulates The Apoptosis of Osteoblasts by Targeting SIRT6Semantic proximity Read

Long non‑coding RNA RP11‑84C13.1 promotes osteogenic differentiation of bone mesenchymal stem cells and alleviates osteoporosis progression via the miR‑23b‑3p/RUNX2 axisSemantic proximity Read

Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional studySemantic proximity Read

MiRNA-483–5p is involved in the pathogenesis of osteoporosis by promoting osteoclast differentiationSemantic proximity Read

Bone marrow mesenchymal stem cell-derived exosomal microRNA-382 promotes osteogenesis in osteoblast via regulation of SLIT2Semantic proximity Read

The mechanism of miR-889 regulates osteogenesis in human bone marrow mesenchymal stem cellsSemantic proximity Read

Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrowSemantic proximity Read

Identification of miRNAs related to osteoporosis by high-throughput sequencingSemantic proximity Read

miR-34a-5p targets Foxp1 to promote osteoclast differentiation and accelerate fracture healingSemantic proximity Read