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Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues

2024-08-19

Abstract excerpt

<h4>ABSTRACT</h4> HIV-1 delivers its genetic material to infect a cell after fusion of the viral and host cell membranes, which takes place after the viral envelope (Env) binds host receptor and co-receptor proteins. Binding of host receptor CD4 to Env results in conformational changes that allow interaction with a host co-receptor (CCR5 or CXCR4). Further conformational rearrangements result in an elongated pre-...

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Literature Corpus work
f3429e55-490c-59a6-9ad7-52a0ca92f160
DOI
10.1101/2024.08.19.608557
Open publication

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Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissuesDOI 10.1101/2024.08.19.608557
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