Article

Surgical Resection and Targeted Therapy in a Pediatric NTRK-Rearranged Low- Grade Spindle Cell Sarcoma: A Case Report

2025-09-23

Abstract excerpt

<title>Abstract</title> <p>Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions have emerged as important oncogenic drivers across a wide range of malignancies, including soft tissue sarcomas. Early detection of these fusions facilitates precision treatment with TRK inhibitors, significantly improving clinical outcomes. However, diagnosing NTRK-rearranged spindle cell neoplasms (NTRK-RSCNs) rem...

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Literature Corpus work: f3307cdb-e55b-515e-b9ef-8c64118123fe
DOI: 10.21203/rs.3.rs-7167572/v1

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