Article

Circadian Rhythm Disruption Aggravates Periodontitis by Promoting M1 Polarization via BMAL1 / IGF-1 signaling axis

2026-05-20

Abstract excerpt

<title>Abstract</title> <p>Aims Epidemiological studies demonstrated that patients with disrupted circadian rhythms had a higher incidence of periodontitis, but the molecular mechanisms remain unknown. This study aimed to investigate the role of the core circadian gene brain and muscle ARNT-Like 1 (BMAL1) in the progression of periodontitis and its mechanisms. Methods Through clinical tissue analysis and the co...

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Literature Corpus work: f3023733-cb7a-5986-9fee-09cc5106a676
DOI: 10.21203/rs.3.rs-9333909/v1

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