Article

Single-Cell Atlas Uncovers Layer 4 Heterogeneity and Functional Gradients in Rhesus Macaque Visual Cortex

2024-03-13

Abstract excerpt

Non-human primates like rhesus macaques are pivotal models for decoding human visual cortex physiology and disorders. We introduce BrainSPACE, an innovative pipeline for rapid and precise brain tissue banking, to sample visual cortex areas: V1, V2, V4, MT, and TEO. Applying snRNA-seq to V1 and V4 (95,071 nuclei), we uncovered conserved GABAergic neuron profiles but stark area-specific diversity in principal neuron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16a9ff08-5667-5d10-988f-833253e542f3
DOI: 10.1101/2024.03.11.584345

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Atlas Uncovers Layer 4 Heterogeneity and Functional Gradients in Rhesus Macaque Visual CortexDOI 10.1101/2024.03.11.584345Read

Transcriptomic cytoarchitecture reveals principles of human neocortex organizationSemantic proximity Read

Charting the Spatial Transcriptome of the Human Cerebral Cortex at Single-Cell ResolutionSemantic proximity Read

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human CortexSemantic proximity Read

Spatial Single-cell Analysis Decodes Cortical Layer and Area SpecificationSemantic proximity Read

Conserved cell types with divergent features between human and mouse cortexSemantic proximity Read

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortexSemantic proximity Read

A platform for efficient identification of molecular phenotypes of brain-wide neural circuits.Semantic proximity Read

Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouseSemantic proximity Read

Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary originsSemantic proximity Read

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortexSemantic proximity Read

A cross-species spatial transcriptomic atlas of the human and non-human primate basal gangliaSemantic proximity Read

Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate RetinaSemantic proximity Read