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A Computational Model of Liver Iron Metabolism

7 Nov 2013

Abstract excerpt

Iron is essential for all known life due to its redox properties; however, these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular control are required to maintain safe levels of iron, and the liver seems to be where this regulation is mainly located. Iron misregulation is implicated in many diseases, and as our understanding...

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PMID: 24244122
DOI: 10.1371/journal.pcbi.1003299

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