Article

Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

2021-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the development of human respiratory tissues is crucial for modeling and treating lung disorders. The molecular details for the specification of lung progenitors from human pluripotent stem cells (hPSCs) are unclear. Here, we use single cell RNA-sequencing with high temporal resolution along an optimized differentiation protocol to determine the transcriptional hierarchy of lung sp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2a81269-89c1-5db4-8591-f84e96502956
DOI: 10.1101/2021.02.23.432413

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitorsDOI 10.1101/2021.02.23.432413Read

Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitorsSemantic proximity Read

A robust human airway organoid platform enables scalable expansion and trajectory mapping of pulmonary neuroendocrine cellsSemantic proximity Read

A single-cell atlas of human fetal lung development between 14 and 19 weeks of gestationSemantic proximity Read

Modeling lung cell development using human pluripotent stem cellsSemantic proximity Read

Derivation of Epithelial‐Only Airway Organoids from Human Pluripotent Stem CellsSemantic proximity Read

Modeling lung cell development using human pluripotent stem cellsSemantic proximity Read

In vitro generation of human pluripotent stem cell derived lung organoidsSemantic proximity Read

Differentiation of human induced pluripotent stem cells into functional airway epitheliumSemantic proximity Read

Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cellsSemantic proximity Read

<i>In vitro</i> induction and <i>in vivo</i> engraftment of lung bud tip progenitor cells derived from human pluripotent stem cellsSemantic proximity Read

A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lungSemantic proximity Read

Developmental origins of cell heterogeneity in the human lungSemantic proximity Read