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Article

Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion.

The Biochemical journal - 1 Mar 2007

Mousson de Camaret Bénédicte, Taanman Jan-Willem, Padet Sylvie, Chassagne Maïté, Mayençon Martine, Clerc-Renaud Pascale, Mandon Ginette, Zabot Marie-Thérèse, Lachaux Alain, Bozon Dominique

Abstract excerpt

DGUOK [dG (deoxyguanosine) kinase] is one of the two mitochondrial deoxynucleoside salvage pathway enzymes involved in precursor synthesis for mtDNA (mitochondrial DNA) replication. DGUOK is responsible for the initial rate-limiting phosphorylation of the purine deoxynucleosides, using a nucleoside triphosphate as phosphate donor. Mutations in the DGUOK gene are associated with the hepato-specific and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17073823
DOI: 10.1042/BJ20060705
PMCID: PMC1798436

Genes

DGUOK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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