Article

MiR-27a as a diagnostic biomarker and potential therapeutic target in systemic sclerosis

2021-08-12

Abstract excerpt

<title>Abstract</title> <p>Background Systemic sclerosis (SSc) or scleroderma is a multiorgan rheumatoid disease characterized by skin tightening or organ dysfunction due to fibrosis, vascular damage, and autoimmunity. No specific cause has been discovered for this illness, and hence no effective treatment exists for it. On the other hand, due to the lack of diagnostic biomarkers capable of effectively and speci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f23eea1c-1317-5669-b166-7ba34539839f
DOI: 10.21203/rs.3.rs-770195/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-27a as a diagnostic biomarker and potential therapeutic target in systemic sclerosisDOI 10.21203/rs.3.rs-770195/v1Read

MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in sclerodermaSemantic proximity Read

MicroRNAs in Systemic Sclerosis: Involvement in Disease Pathogenesis and Potential Use as Diagnostic Biomarkers and Therapeutic TargetsSemantic proximity Read

microRNA27a-3p mediates reduction of the Wnt antagonist sFRP-1 in systemic sclerosisSemantic proximity Read

MicroRNA-27a-3p inhibits lung and skin fibrosis of systemic sclerosis by negatively regulating SPP1Semantic proximity Read

MicroRNA-29: a potential therapeutic target for systemic sclerosisSemantic proximity Read

Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAsSemantic proximity Read

Circulating miRNA-181b-5p, miRNA-223-3p, miRNA-210-3p, let 7i-5p, miRNA-21-5p and miRNA-29a-3p in patients with localized scleroderma as potential biomarkersSemantic proximity Read

Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosisSemantic proximity Read

Bioinformatics-integrated screening of systemic sclerosis-specific expressed markers to identify therapeutic targetsSemantic proximity Read

The role of microRNAs in autoimmune diseases with skin involvement.Semantic proximity Read

The Role of Non‐Coding RNA in Systemic Sclerosis: From Mechanism to TranslationSemantic proximity Read

A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathwaysSemantic proximity Read