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Article

microRNA27a-3p mediates reduction of the Wnt antagonist sFRP-1 in systemic sclerosis

23 Sept 2020

Abstract excerpt

Systemic Sclerosis (SSc) is an autoimmune connective tissue disease that leads to skin and lung fibrosis. The Wnt pathway is clearly elevated in SSc and is pro-fibrotic via activation of canonical Wnt signalling. sFRP-1 is a Wnt antagonist that acts as a negative regulator of Wnt signalling. We sought to measure the levels of serum sFRP-1 in early diffuse SSc patients compared to healthy controls and if this is...

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PMID: 32965161
DOI: 10.1080/15592294.2020.1827715

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