Article

Assessing <i>Corynebacterium glutamicum</i> as a surrogate of <i>Mycobacterium tuberculosis</i> for DNA gyrase inhibitor design

2026-06-24

Abstract excerpt

<h4>ABSTRACT</h4> DNA gyrase is an essential bacterial enzyme and a clinically validated target for the treatment of tuberculosis. However, the discovery of new inhibitors remains limited by the many challenges regarding the manipulation on pathogenic mycobacteria. This study validates Corynebacterium glutamicum ( Cglu ) as a safe, non-pathogenic surrogate for Mycobacterium tuberculosis ( Mtb ) to investigate...

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Literature Corpus work: f13f7e1f-d5e1-5934-b8d5-221ed7bdc38c
DOI: 10.64898/2026.06.24.734172

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