Article

Somatic Mutations within Myocilin due to Aging may be a Potential Risk Factor for Glaucoma.

2023-01-20

Abstract excerpt

Glaucoma is a chronic optic neuropathy that leads to irreversible vision loss. Aging and family history are the two most important risk factors of glaucoma. One of the most studied genes involved with the onset of open angle glaucoma is myocilin ( MYOC ). About 105 germline mutations within MYOC are known to be associated with glaucoma and result in endoplasmic reticulum (ER) stress that leads to trabecular meshwo...

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Literature Corpus work: f12753d7-193c-51b7-9fb5-6568280291e8
DOI: 10.21203/rs.3.rs-2447725/v1

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