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Article

Cross-talk between MYOC p. Y437H mutation and TGF-β2 in the pathology of glaucoma.

International journal of medical sciences - 1 Jan 2020

Yang Yang, Abdulatef Al Sabri Waled Abdulghani, Zhang LuSi, Jiang Haibo, Zeng Zhou, Li Haibo, Xia Xiaobo

Abstract excerpt

Objective: To identify the interaction between the MYOC Y437H mutation and TGF-β2 in a family with primary open-angle glaucoma (POAG). Methods: The MYOC Y437H mutation was identified in a family with POAG; the family was a fourth-generation family with 27 members, of which 6 members were affected. Analysis focused on the secreted myocilin protein and TGF-β2 found in the aqueous humor. Samples were taken both from...

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Source

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Identifiers

PMID: 32410836
DOI: 10.7150/ijms.43614
PMCID: PMC7211149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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