Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NLRC4 inflammasomopathies.

Current opinion in allergy and clinical immunology - 1 Dec 2017

Romberg Neil, Vogel Tiphanie P, Canna Scott W

Abstract excerpt

PURPOSE OF REVIEW: The purpose of the review is to highlight developments in autoinflammatory diseases associated with gain-of-function mutations in the gene encoding NLR-family CARD-containing protein 4 (NLRC4), the NLRC4-inflammasomopathies. RECENT FINDINGS: Three years since the identification of the first autoinflammation with infantile enterocolitis (AIFEC) patients, there is an improved understanding of how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Biomarkers, Tumor
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CARD Signaling Adaptor Proteins

Share to Inflammasomes

Share to Inflammation

Share to Interleukin-18

Share to Urticaria

Source

Open in PubMed Open full text

Identifiers

PMID: 28957823
DOI: 10.1097/ACI.0000000000000396
PMCID: PMC6070355

Genes

NLRC4
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NLRC4 inflammasomopathies.PMID 28957823Read ↗

Three cases of autoinflammatory disease with novel NLRC4 mutations, and the first mutation reported in the CARD domain of NLRC4 associated with autoinflammatory infantile enterocolitis (AIFEC).Semantic proximity Read ↗

Early-onset recurrent panniculitis as a phenotype of NLRC4-associated autoinflammatory syndrome: Characterization of pathogenicity of the p.Ser445Pro NLRC4 variant.Semantic proximity Read ↗

Somatic Mosaic NLRC4 Variants in Autoinflammatory Diseases: Functional Characterization and Correlation of Mosaicism Levels with Disease Age of Onset and Severity.Semantic proximity Read ↗

Challenges in the Diagnosis of Infantile Enterocolitis and RareAuto-inflammatory Syndromes: A Case Report and Literature ReviewSemantic proximity Read ↗

[NLRC4 associated autoinflammatory diseases: A systematic review of the current literature].Semantic proximity Read ↗

A clinical update on inflammasomopathies.Semantic proximity Read ↗

First Description of Late‐Onset Autoinflammatory Disease Due to Somatic NLRC4 MosaicismSemantic proximity Read ↗

An inherited mutation in NLRC4 causes autoinflammation in human and mice.Semantic proximity Read ↗

An animal model for autoinflammation with infantile enterocolitisSemantic proximity Read ↗

Inflammatory turmoil within: an exploration of autoinflammatory disease genetic underpinnings, clinical presentations, and therapeutic approachesSemantic proximity Read ↗

Contrasting role of NLRP12 in autoinflammation: evidence from a case report and mouse models.Semantic proximity Read ↗

NLRP12-associated systemic autoinflammatory diseases in children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.