Article

Intact messenger RNA exists in human blood plasma and urine, and their purified macromolecular compartments

2024-11-30

Abstract excerpt

It is generally assumed that extracellular long RNA molecules in biofluids are fragmented. Few studies have indirectly hinted at the existence of possibly functional, intact long RNA transcripts. In search for such RNA molecules, we developed a long-read full transcript sequencing workflow for low-input and low-quality samples. We applied our method to human blood plasma, urine, and their isolated macromolecular c...

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Literature Corpus work: f0ea5e24-d3e6-5e74-bcb9-f1e23678e7ad
DOI: 10.1101/2024.11.30.626091

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