Article

Ion Channels as Targets of the Vitamin D Receptor: A Long Journey with a Promising Future

2025-12-24

Abstract excerpt

The vitamin D receptor (VDR) acts as both a nuclear transcription factor and a non-genomic mediator that regulates a broad spectrum of physiological processes beyond calcium and phosphate homeostasis. VDR plays an important role in the modulation of ion channels across multiple tissues, including osteoblasts, renal and intestinal epithelial cells, neurons, and vascular smooth muscle. These regulatory mechanisms en...

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Literature Corpus work: f0e9f3a8-3c19-5651-a553-d02a9873c0ec
DOI: 10.20944/preprints202512.1956.v1

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