Article
Vitamin D resistance.
Best practice & research. Clinical endocrinology & metabolism - 1 Dec 2006
Bouillon Roger, Verstuyf Annemieke, Mathieu Chantal, Van Cromphaut Sophie, Masuyama Ritsuko, Dehaes Petra, Carmeliet Geert
Abstract excerpt
Vitamin D is a secosteroid of nutritional origin but can also be generated in the skin by ultraviolet light. After two hydroxylations 1,25-(OH)2 vitamin D avidly binds and activates the vitamin D receptor (VDR), a nuclear transcription factor, hereby regulating a large number of genes. The generation of VDR deficient mice has expanded the knowledge on vitamin D from a calcium-regulating hormone to a humoral...
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