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Article

Molecular Actions of 1,25-Dihydroxyvitamin D3 on Genes Involved in Calcium Homeostasis

1 Dec 2007

Abstract excerpt

1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] functions in vertebrate organisms as a primary regulator of calcium and phosphorus homeostasis, an activity that is achieved through direct actions on gene expression in intestine, kidney, and bone. Recent studies have identified novel genes such as TRPV5, TRPV6, and RANKL whose products are integral to the maintenance of extracellular calcium. The objective of this...

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PMID: 18290714
DOI: 10.1359/jbmr.07s207

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