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Article

Cellular aging is accelerated in the malignant clone of myeloproliferative neoplasms

2023-09-12

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are caused by somatic driver mutations, such as JAK2 V617F , which might also affect cellular aging and senescence. Here, we analyzed the heterogeneity of aging in MPN patients and if this can be used to specifically target malignant cells. The mean epigenetic age was significantly accelerated in 129 MPN patients across all disease-entities, whereas premature telomere attrition...

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Identifiers and source

Literature Corpus work
f0c76a98-6050-5b5f-ad4d-20bb1f919288
DOI
10.1101/2023.09.12.23295349
Open publication

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Cellular aging is accelerated in the malignant clone of myeloproliferative neoplasmsDOI 10.1101/2023.09.12.23295349
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