Article

Lymphocyte mitochondrial genome integrity is not altered by cladribine

2023-03-20

Abstract excerpt

Cladribine tablets are a treatment for multiple sclerosis (MS) with effects on lymphocytes’, yet its mode of action has not been fully established. Here, we evaluated the effects of cladribine on mitochondrial DNA integrity in human lymphocytes. We treated cultured human T-cell lines (CCRF-CEM and Jurkat) with varying concentrations of cladribine to mimic the slow cell depletion observed in MS. The CCRF-CEM were s...

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Literature Corpus work: f08faa77-fb73-568b-b937-4dbbc0fcf678
DOI: 10.21203/rs.3.rs-2672926/v1

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