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Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency

9 Feb 2021

Abstract excerpt

Rationale: NAA15 (N-alpha-acetyltransferase 15) is a component of the NatA (N-terminal acetyltransferase complex). The mechanism by which NAA15 haploinsufficiency causes congenital heart disease remains unknown. To better understand molecular processes by which NAA15 haploinsufficiency perturbs cardiac development, we introduced NAA15 variants into human induced pluripotent stem cells (iPSCs) and assessed the...

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PMID: 33557580
DOI: 10.1161/circresaha.120.316966

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