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A microfluidic approach for sequential assembly of siRNA polyplexes with defined structure – activity relationship

2019-04-20

Abstract excerpt

Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplexes are prepared manually by mixing two components: polyanionic nucleic acids and polycations. However, parameters such as internal structure, size, polydispersity and su...

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Literature Corpus work
f06696ed-83d2-58dd-9cc4-83e1ebcdffa2
DOI
10.7287/peerj.preprints.27669v1
Open publication

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A microfluidic approach for sequential assembly of siRNA polyplexes with defined structure – activity relationshipDOI 10.7287/peerj.preprints.27669v1
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