Article

Gene knockdown in HaCaT cells by small interfering RNAs entrapped in grapefruit- derived extracellular vesicles using a microfluidic device

2022-11-01

Abstract excerpt

Small interfering RNAs (siRNAs) knockdown the expression of target genes by causing mRNA degradation and are a promising therapeutic modality. In clinical practice, lipid nanoparticles (LNPs) are used to deliver RNAs, such as siRNA and mRNA, into cells. However, these artificial nanoparticles are toxic and immunogenic. Thus, we focused on extracellular vesicles (EVs), natural drug delivery systems, for the deliver...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d780c96e-feb5-57d0-a815-1e84d041b646
DOI: 10.21203/rs.3.rs-2189478/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene knockdown in HaCaT cells by small interfering RNAs entrapped in grapefruit- derived extracellular vesicles using a microfluidic deviceDOI 10.21203/rs.3.rs-2189478/v1Read

Harnessing extracellular vesicles for efficient siRNA delivery <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Conventional and microfluidic methods: Design and optimization of lipid-polymeric hybrid nanoparticles for gene therapySemantic proximity Read

Development of Cell-Derived Plasma Membrane Vesicles as a Nanoparticle Encapsulation and Delivery SystemSemantic proximity Read

Optimizing of a suitable protocol for isolating tissue‐derived extracellular vesicles and profiling small RNA patterns in hepatocellular carcinomaSemantic proximity Read

Microfluidic and Nanofluidic Intracellular DeliverySemantic proximity Read

Red blood Cell-derived Extracellular Vesicles as biomaterials: the opportunity of freezing-induced accelerated agingSemantic proximity Read

Harnessing hydrodynamics for high-yield production of extracellular vesicles from stem cells spheroids with specific cargo profilingSemantic proximity Read

CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing LossSemantic proximity Read

A Microfluidic Device to Enhance Viral Transduction Efficiency During Manufacture of Engineered Cellular TherapiesSemantic proximity Read

Engineering asymmetric nanoscale lipid vesicles for drug deliverySemantic proximity Read

Nanoencapsulation of Hirudo medicinalis proteins in liposomes as a nanocarrier for inhibiting angiogenesis through targeting VEGFA in the Breast cancer cell line (MCF-7)Semantic proximity Read

Nanotechnology and microfluidics : formulation design and on-chip manufacture of nanoparticlesSemantic proximity Read