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Towards more accurate preclinical glioblastoma modelling: reverse translation of clinical standard of care in a glioblastoma mouse model

2021-06-18

Abstract excerpt

<h4>Introduction</h4> Contrarily to clinical trials, where glioblastoma (GBM) patients are usually heavily pre-treated (surgery, radiotherapy (RT) and temozolomide (TMZ)) before receiving the experimental therapies, in preclinical GBM studies experimental treatments have mostly been administered as monotherapy or combined with a very limited part of the clinical standard of care. This discrepancy can explain the...

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Literature Corpus work
f05088d8-8536-5fd1-a1d2-3857774bfef8
DOI
10.1101/2021.06.17.448792
Open publication

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Towards more accurate preclinical glioblastoma modelling: reverse translation of clinical standard of care in a glioblastoma mouse modelDOI 10.1101/2021.06.17.448792
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