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Article

Polyphosphate is a primordial chaperone.

Molecular cell - 6 Mar 2014

Gray Michael J, Wholey Wei-Yun, Wagner Nico O, Cremers Claudia M, Mueller-Schickert Antje, Hock Nathaniel T, Krieger Adam G, Smith Erica M, Bender Robert A, Bardwell James C A, Jakob Ursula

Abstract excerpt

Composed of up to 1,000 phospho-anhydride bond-linked phosphate monomers, inorganic polyphosphate (polyP) is one of the most ancient, conserved, and enigmatic molecules in biology. Here we demonstrate that polyP functions as a hitherto unrecognized chaperone. We show that polyP stabilizes protein...

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Identifiers

PMID: 24560923
DOI: 10.1016/j.molcel.2014.01.012
PMCID: PMC3996911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24560923-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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