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Article

Polyphosphate is a primordial chaperone.

Molecular cell - 6 Mar 2014

Gray Michael J, Wholey Wei-Yun, Wagner Nico O, Cremers Claudia M, Mueller-Schickert Antje, Hock Nathaniel T, Krieger Adam G, Smith Erica M, Bender Robert A, Bardwell James C A, Jakob Ursula

Abstract excerpt

Composed of up to 1,000 phospho-anhydride bond-linked phosphate monomers, inorganic polyphosphate (polyP) is one of the most ancient, conserved, and enigmatic molecules in biology. Here we demonstrate that polyP functions as a hitherto unrecognized chaperone. We show that polyP stabilizes proteins in vivo, diminishes the need for other chaperone systems to survive proteotoxic stress conditions, and protects a...

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Identifiers

PMID: 24560923
DOI: 10.1016/j.molcel.2014.01.012
PMCID: PMC3996911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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