Article

SARS-CoV-2 Spike S1 glycoprotein is a TLR4 agonist, upregulates ACE2 expression and induces pro-inflammatory M <sub>1</sub> macrophage polarisation

2021-08-11

Abstract excerpt

<h4>Background and aims</h4> TLR4 is an important innate immune receptor that recognizes bacterial LPS, viral proteins and other pathogen associated molecular patterns (PAMPs). It is expressed on tissue-resident and immune cells. We previously proposed a model whereby SARS-CoV-2 activation of TLR4 via its spike glycoprotein S1 domain increases ACE2 expression, viral loads and hyperinflammation with COVID-19 disea...

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Literature Corpus work: efe799e8-3f5c-57c0-b6cd-318fff38612c
DOI: 10.1101/2021.08.11.455921

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