Unraveling the Molecular Cross-talk in the Comorbidity of Multiple Myeloma and Systemic Light-Chain Amyloidosis through Multi-Dataset Analysis

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> The co-occurrence of multiple myeloma (MM) and light-chain amyloidosis (AL) accelerates disease progression, but their shared mechanisms remain unclear. <bold>Methods:</bold> We integrated bulk transcriptomic (GSE6477, GSE16558, GSE175384) and single-cell RNA-seq (GSE188222, GSE271107) data. Using WGCNA, PPI networks, and machine learning, we developed a pr...

Topics

Open a Topic to create a Post that cites this publication.

• Bayes Theorem
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Multiple Myeloma
• Multiple Myeloma Research and Treatments
• Polymorphism, Single Nucleotide
• Proteome
• Risk Factors

Identifiers and source

Literature Corpus work

efe4f5bb-eedd-5adf-813f-c887d0d24294

DOI

10.21203/rs.3.rs-7555168/v1