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Article

Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma

13 Feb 2023

Abstract excerpt

Multiple myeloma (MM) is a highly refractory hematologic cancer. Targeted immunotherapy has shown promise in MM but remains hindered by the challenge of identifying specific yet broadly representative tumor markers. We analyzed 53 bone marrow (BM) aspirates from 41 MM patients using an unbiased, high-throughput pipeline for therapeutic target discovery via single-cell transcriptomic profiling, yielding 38 MM...

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PMID: 36779841
DOI: 10.1158/0008-5472.can-22-1769

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