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Article

Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma.

BMC medicine - 29 Sept 2023

Wang Qiangsheng, Shi Qiqin, Wang Zhenqian, Lu Jiawen, Hou Jian

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targets. METHODS: First, we comprehensively investigated the causal association between 2994 proteins and MM through two-sample mendelian randomization (MR) analysis using summary-level data from...

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Identifiers

PMID: 37775746
DOI: 10.1186/s12916-023-03086-0
PMCID: PMC10542236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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