Article

Extensive monolayer formation after transplantation depends on a RPE subpopulation derived from human iPSCs

2024-10-15

Abstract excerpt

<h4>Summary</h4> Loss of the retinal pigment epithelium (RPE) in the eye leads to photoreceptor dysfunction and death causing eventually vision loss. Cell replacement strategies using RPE cells derived in vitro from pluripotent stem cells (PSCs) are currently evaluated as a potential therapeutic strategy. Generation of polarized monolayers represents an essential prerequisite for proper RPE function, however, mo...

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Literature Corpus work: efc660ba-2ed9-5087-bdc0-098348a89e6a
DOI: 10.1101/2024.10.15.618147

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