Article

High resolution kinematic approach for quantifying impaired mobility of dystrophic zebrafish larvae

2024-12-09

Abstract excerpt

Dystrophin-deficient zebrafish larvae are a small, genetically tractable vertebrate model of Duchenne muscular dystrophy well suited for early stage therapeutic development. However, current approaches for evaluating their impaired mobility, a physiologically relevant therapeutic target, are characterized by low resolution and high variability. To address this, we used high speed videography and deep learning-base...

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Literature Corpus work: 2ac01712-89db-53c0-a173-d3089762cf07
DOI: 10.1101/2024.12.05.627004

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