Article

Cross species computational analysis of dopamine and MPP plus binding to the dopamine transporter elucidates mechanisms of MPTP induced neurotoxicity

2026-01-08

Abstract excerpt

<title>Abstract</title> <p>1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces parkinsonism through its toxic metabolite, 1-methyl-4-phenylpyridinium (MPP+), which structurally mimics dopamine and enters dopaminergic neurons via the dopamine transporter (DAT). Although zebrafish are increasingly used as an MPTP-induced parkinsonian model due to their genetic and functional similarity to humans, direct mol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: efae720b-b976-5ae1-a653-9d2d5e8a16f8
DOI: 10.21203/rs.3.rs-8417718/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross species computational analysis of dopamine and MPP plus binding to the dopamine transporter elucidates mechanisms of MPTP induced neurotoxicityDOI 10.21203/rs.3.rs-8417718/v1Read

Comparative Computational Docking Analysis of MPP+ and Dopamine Binding to Dopamine Transporter in Human and Zebrafish: Mechanistic Insights into MPTP NeurotoxicitySemantic proximity Read

Hybrid modeling of Parkinsons disease integrating zebrafish neurobiology with in silico predictive analyticsSemantic proximity Read

1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine induced Parkinson's disease in zebrafishSemantic proximity Read

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Treated Adult Zebrafish as a Model for Parkinson’s DiseaseSemantic proximity Read

A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric diseaseSemantic proximity Read

Spondias mombin flavonoids showed super-binder ability with Downstream Molecular Targets of Parkinson’s Disease: Folkloric-therapy assessment as a Scaffold for Structural Studies in Neurodegenerative diseaseSemantic proximity Read

Structural Genomics of the Human Dopamine Receptor SystemSemantic proximity Read

Psychomotor Impairments and Therapeutic Implications Revealed by a Mutation Associated with Infantile Parkinsonism-DystoniaSemantic proximity Read

Motor and Non-Motor Effects of Acute MPTP in Adult Zebrafish: Insights into Parkinson’s DiseaseSemantic proximity Read

Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-DystoniaSemantic proximity Read

Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model.Semantic proximity Read

Motor and Non-Motor Effects of Acute Mptp in Adult Zebrafish: Insights into Parkinson’s DiseaseSemantic proximity Read