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Article

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond.

The Journal of cell biology - 14 Dec 2009

Ilieva Hristelina, Polymenidou Magdalini, Cleveland Don W

Abstract excerpt

Selective degeneration and death of one or more classes of neurons is the defining feature of human neurodegenerative disease. Although traditionally viewed as diseases mainly affecting the most vulnerable neurons, in most instances of inherited disease the causative genes are widely-usually ubiquitously-expressed. Focusing on amyotrophic lateral sclerosis (ALS), especially disease caused by dominant mutations in...

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Identifiers

PMID: 19951898
DOI: 10.1083/jcb.200908164
PMCID: PMC2806318

Genes

SOD1

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