Article

An explainable predictive machine learning model of oxaliplatin induced peripheral neuropathy based on clinical data: a retrospective single center

2025-12-01

Abstract excerpt

<title>Abstract</title> <p>Background Oxaliplatin, a third-generation platinum-based antineoplastic agent, is widely used in the treatment of gastrointestinal malignancies such as colorectal cancer. However, oxaliplatin-induced peripheral neuropathy (OIPN) is a common and distinctive adverse effect, with a high incidence rate. Characterized by numbness and paresthesia in the extremities, OIPN is dose-limiting, of...

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Literature Corpus work: ef70a627-7628-5b59-a1c9-fda8bfd8ef10
DOI: 10.21203/rs.3.rs-7911184/v1

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