Article

Targeted spatial profiling identifies a CD8A − LARS axis associated with neoadjuvant chemotherapy resistance in triple-negative breast cancer

2026-05-13

Abstract excerpt

<title>Abstract</title> <p> Background Triple-negative breast cancer (TNBC) accounts for approximately 10–20% of all breast cancers and is characterized by aggressive clinical behavior and poor prognosis. Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) is associated with a good prognosis. Recently, the addition of pembrolizumab to NAC has improved pCR and overall survival. However, TNB...

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Literature Corpus work: e3258f4c-5c11-5782-be65-a8a20e52b489
DOI: 10.21203/rs.3.rs-9572543/v1

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