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Article

An Overview of Recent Therapeutics Advances for Duchenne Muscular Dystrophy.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Mah Jean K

Abstract excerpt

Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy in childhood. Mutations of the DMD gene destabilize the dystrophin associated glycoprotein complex in the sarcolemma. Ongoing mechanical stress leads to unregulated influx of calcium ions into the sarcoplasm, with activation of proteases, release of proinflammatory cytokines, and mitochondrial dysfunction. Cumulative damage and...

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Source

Identifiers

PMID: 29067652
DOI: 10.1007/978-1-4939-7374-3_1

Genes

DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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