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Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

International journal of experimental pathology - 1 Jun 2005

Lee Hyoung-Gon, Castellani Rudy J, Zhu Xiongwei, Perry George, Smith Mark A

Abstract excerpt

While the pathogenesis of Alzheimer's disease (AD) is unclear, amyloid-beta plaques remain major lesions in the brain of individuals with AD. Likewise, amyloid-beta is one of the best-studied proteins relating to the pathogenesis of AD. Indeed, the pathological diagnosis of AD tends to be congruous with the quantity of amyloid-beta. However, it is important to recognize that pathological diagnosis merely...

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Identifiers

PMID: 15910547
DOI: 10.1111/j.0959-9673.2005.00429.x
PMCID: PMC2517413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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