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Type 2 diabetes and fracture risk: deciphering the complex relationship with both genetic and observational evidence

2023-06-29

Abstract excerpt

The “diabetic bone paradox” suggested that type 2 diabetes (T2D) patients would have higher areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In this study, we found that the genetically predicted T2D was associated with higher BMD and lower risk of fracture in both wGRS and two-sample MR analyses. We also identified ten genomic loci shared between T2D and fracture, with the t...

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Literature Corpus work
eee68a41-8565-5339-aa4c-522b0eef73eb
DOI
10.1101/2023.06.23.23291786
Open publication

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Type 2 diabetes and fracture risk: deciphering the complex relationship with both genetic and observational evidenceDOI 10.1101/2023.06.23.23291786
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