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Genetically determined type 1 diabetes mellitus and risk of osteoporosis.

Experimental gerontology - 15 Jun 2024

Cheng Ting, Hou Jia-Lin, Han Zi-Yi, Geng Xin-Lei, Zhang Yao-Chen, Fan Ke-Yi, Liu Liu, Zhang He-Yi, Huo Yue-Hong, Li Xiao-Feng, Zhang Sheng-Xiao

Abstract excerpt

BACKGROUND: Observational evidence suggests that type 1 diabetes mellitus (T1DM) is associated with the risk of osteoporosis (OP). Nevertheless, it is not apparent whether these correlations indicate a causal relationship. To elucidate the causal relationship, a two-sample Mendelian randomization (MR) analysis was performed. METHODS: T1DM data was obtained from the large genome-wide association study (GWAS), in...

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PMID: 38636571
DOI: 10.1016/j.exger.2024.112434

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