Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury

Abstract excerpt

The lungs have a remarkable capacity to repair. However, repetitive injury can lead to progressive fibrosis and end-stage organ failure. Whether tissue-resident mesenchymal cell populations retain epigenetic memory of prior injuries that contribute to this pathological process is unknown. Here we used a genetic lineage labeling approach to mark the lung mesenchyme prior to injury, then performed multi-modal analys...

Topics

Open a Topic to create a Post that cites this publication.

• Congenital Anomalies and Fetal Surgery
• Congenital Diaphragmatic Hernia Studies
• Congenital heart defects research
• Neonatal Respiratory Health Research
• Tracheal and airway disorders

Identifiers and source

Literature Corpus work

eeb2eff3-b6f6-5d48-95c7-ee31056ec3e7

DOI

10.1101/2022.03.04.483065