Article

Heterogeneous Treatment Effects in HFpEF: Distinguishing Drug-Specific Response from Prognostic Phenotypes Across Randomized Trials

2026-07-09

Abstract excerpt

<h4>Background</h4> Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome comprising multiple pathophysiological phenotypes. HFpEF trials have largely enrolled diverse populations and reported average treatment effects, consistently yielding neutral results that may obscure drug-specific benefits within distinct subgroups. To address this issue, we employ an interaction-based that inc...

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Literature Corpus work: ee574f04-2992-5b34-8584-fc2b4f4ecc21
DOI: 10.64898/2026.07.06.26357251

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