Article

Physiology-Informed Digital Twin-AI Framework Predicts Pacing Therapy Response in HFpEF

2026-03-09

Abstract excerpt

<h4>Background and Aims</h4> Heart failure with preserved ejection fraction (HFpEF) exhibits profound phenotypic heterogeneity, which likely contributes to variable therapeutic response. We developed a physiology-informed digital twin–AI framework to predict individual hemodynamic and myocardial energetic responses to accelerated atrial pacing and tested whether simulated physiologic response corresponds to respo...

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Literature Corpus work: ba786be6-35b1-5eb3-a470-03f60bc7fa2d
DOI: 10.64898/2026.03.06.26347199

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