Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants.

Medical microbiology and immunology - 1 Aug 2023

Haycroft Ebene R, Davis Samantha K, Ramanathan Pradhipa, Lopez Ester, Purcell Ruth A, Tan Li Lynn, Pymm Phillip, Wines Bruce D, Hogarth P Mark, Wheatley Adam K, Juno Jennifer A, Redmond Samuel J, Gherardin Nicholas A, Godfrey Dale I, Tham Wai-Hong, Selva Kevin John, Kent Stephen J, Chung Amy W

Abstract excerpt

Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The SARS-CoV-2 receptor-binding domain (RBD) is a hotspot for mutations, reflecting its critical role at the ACE2 interface during viral entry. Here, we comprehensively investigated the impact of RBD mutations, including 5 variants of concern (VOC) or interest-including Omicron (BA.2)-and 33 common...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin G

Share to Mutation

Share to Receptors, IgG

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 37477828
DOI: 10.1007/s00430-023-00773-w
PMCID: PMC10372118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants.PMID 37477828Read ↗

Altered affinity to ACE2 and reduced Fc functional antibodies to SARS-CoV-2 RBD variantsSemantic proximity Read ↗

COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutantsSemantic proximity Read ↗

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD bindingSemantic proximity Read ↗

Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.Semantic proximity Read ↗

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read ↗

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains.Semantic proximity Read ↗

Structural insight into antibody evasion of SARS-CoV-2 omicron variantSemantic proximity Read ↗

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read ↗

Human serum from SARS-CoV-2 vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variantSemantic proximity Read ↗

Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 VariantsSemantic proximity Read ↗

Differences between Omicron SARS-CoV-2 RBD and other variants in their ability to interact with cell receptors and monoclonal antibodiesSemantic proximity Read ↗

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.